Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high-fat diet and streptozotocin.
Identifieur interne : 000109 ( Main/Exploration ); précédent : 000108; suivant : 000110Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high-fat diet and streptozotocin.
Auteurs : Xi Chen [République populaire de Chine] ; Huaibo Yuan [République populaire de Chine] ; Fangfang Shi [République populaire de Chine] ; Yudong Zhu [République populaire de Chine]Source :
- Journal of the science of food and agriculture [ 1097-0010 ] ; 2020.
Descripteurs français
- KwdFr :
- Alimentation riche en graisse (MeSH), Animaux (MeSH), Antioxydants (métabolisme), Catalase (métabolisme), Cholestérol HDL (sang), Cholestérol LDL (sang), Diabète expérimental (prévention et contrôle), Extraits de plantes (pharmacologie), Fragmentation de l'ADN (MeSH), Glutathion (métabolisme), Glutathione peroxidase (métabolisme), Glycémie (métabolisme), Hypoglycémiants (pharmacologie), Hémoglobine A glycosylée (métabolisme), Insuline (sang), Lepidium sativum (composition chimique), Lipides (sang), Malonaldéhyde (métabolisme), Mâle (MeSH), Peroxydes lipidiques (métabolisme), Phosphatidylinositol 3-kinases (génétique), Phosphatidylinositol 3-kinases (métabolisme), Régulation de l'expression des gènes (MeSH), Souris (MeSH), Souris de lignée ICR (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Substrats du récepteur à l'insuline (génétique), Substrats du récepteur à l'insuline (métabolisme), Superoxide dismutase (métabolisme), Transporteur de glucose de type 4 (génétique), Transporteur de glucose de type 4 (métabolisme), Triglycéride (sang).
- MESH :
- composition chimique : Lepidium sativum.
- effets des médicaments et des substances chimiques : Stress oxydatif.
- génétique : Phosphatidylinositol 3-kinases, Substrats du récepteur à l'insuline, Transporteur de glucose de type 4.
- métabolisme : Antioxydants, Catalase, Glutathion, Glutathione peroxidase, Glycémie, Hémoglobine A glycosylée, Malonaldéhyde, Peroxydes lipidiques, Phosphatidylinositol 3-kinases, Substrats du récepteur à l'insuline, Superoxide dismutase, Transporteur de glucose de type 4.
- pharmacologie : Extraits de plantes, Hypoglycémiants.
- prévention et contrôle : Diabète expérimental.
- sang : Cholestérol HDL, Cholestérol LDL, Insuline, Lipides, Triglycéride.
- Alimentation riche en graisse, Animaux, Fragmentation de l'ADN, Mâle, Régulation de l'expression des gènes, Souris, Souris de lignée ICR.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (metabolism), Blood Glucose (metabolism), Catalase (metabolism), Cholesterol, HDL (blood), Cholesterol, LDL (blood), DNA Fragmentation (MeSH), Diabetes Mellitus, Experimental (prevention & control), Diet, High-Fat (MeSH), Gene Expression Regulation (MeSH), Glucose Transporter Type 4 (genetics), Glucose Transporter Type 4 (metabolism), Glutathione (metabolism), Glutathione Peroxidase (metabolism), Glycated Hemoglobin A (metabolism), Hypoglycemic Agents (pharmacology), Insulin (blood), Insulin Receptor Substrate Proteins (genetics), Insulin Receptor Substrate Proteins (metabolism), Lepidium sativum (chemistry), Lipid Peroxides (metabolism), Lipids (blood), Male (MeSH), Malondialdehyde (metabolism), Mice (MeSH), Mice, Inbred ICR (MeSH), Oxidative Stress (drug effects), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Plant Extracts (pharmacology), Superoxide Dismutase (metabolism), Triglycerides (blood).
- MESH :
- chemical , blood : Cholesterol, HDL, Cholesterol, LDL, Insulin, Lipids, Triglycerides.
- chemical , genetics : Glucose Transporter Type 4, Insulin Receptor Substrate Proteins.
- chemical , metabolism : Antioxidants, Blood Glucose, Catalase, Glucose Transporter Type 4, Glutathione, Glutathione Peroxidase, Glycated Hemoglobin A, Insulin Receptor Substrate Proteins, Lipid Peroxides, Malondialdehyde, Superoxide Dismutase.
- chemical , pharmacology : Hypoglycemic Agents, Plant Extracts.
- chemistry : Lepidium sativum.
- drug effects : Oxidative Stress.
- genetics : Phosphatidylinositol 3-Kinases.
- metabolism : Phosphatidylinositol 3-Kinases.
- prevention & control : Diabetes Mellitus, Experimental.
- Animals, DNA Fragmentation, Diet, High-Fat, Gene Expression Regulation, Male, Mice, Mice, Inbred ICR.
Abstract
BACKGROUND
A mouse model in which diabetes mellitus was induced by low-dose streptozotocin (STZ) injection combined with a high-fat diet was used to study the effect of two water cress (Lepidium savitum) preparations. Diabetic mice were treated with dried cress powder or with water-soluble extracts (tested at two doses), together with proper control groups. The mice were evaluated after 4 weeks of continuous intervention for type 2 diabetic and associated markers. We determined blood glucose, body weight, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum insulin levels, and DNA integrity of hepatic cells. The concentrations of malondialdehyde (MDA) and lipid peroxide (LPO) and the activities of four enzymes that are part of the antioxidant defense system were determined in liver samples, as well as gene expression (by semi-quantitative reverse transcription polymerase chain reaction) and enzyme activity of IRS-1, IRS-2, PI3K, AKT-2, and GLUT4.
RESULTS
After 4 weeks of intervention, the levels of TC, TG, and LDL cholesterol were significantly (P < 0.5) decreased and HDL cholesterol was significantly increased. Enzyme activities of liver superoxide dismutase, glutathione, glutathione peroxidase, and catalase were significantly increased, whereas MDA and LPO concentrations were significantly reduced. The transcription level of the five genes assessed was increased, with corresponding increases in protein expression.
CONCLUSION
Oral uptake of garden cress can significantly reduce the blood glucose and improve the blood lipid metabolism of diabetic mice. Considerable improvements in the activity of antioxidant defense enzymes were observed in type 2 diabetic mice that improved the body's antioxidant emergency response. © 2019 Society of Chemical Industry.
DOI: 10.1002/jsfa.10230
PubMed: 31875960
Affiliations:
Links toward previous steps (curation, corpus...)
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(MeSH)</term><term>Antioxidants (metabolism)</term><term>Blood Glucose (metabolism)</term><term>Catalase (metabolism)</term><term>Cholesterol, HDL (blood)</term><term>Cholesterol, LDL (blood)</term><term>DNA Fragmentation (MeSH)</term><term>Diabetes Mellitus, Experimental (prevention & control)</term><term>Diet, High-Fat (MeSH)</term><term>Gene Expression Regulation (MeSH)</term><term>Glucose Transporter Type 4 (genetics)</term><term>Glucose Transporter Type 4 (metabolism)</term><term>Glutathione (metabolism)</term><term>Glutathione Peroxidase (metabolism)</term><term>Glycated Hemoglobin A (metabolism)</term><term>Hypoglycemic Agents (pharmacology)</term><term>Insulin (blood)</term><term>Insulin Receptor Substrate Proteins (genetics)</term><term>Insulin Receptor Substrate Proteins (metabolism)</term><term>Lepidium sativum (chemistry)</term><term>Lipid Peroxides (metabolism)</term><term>Lipids (blood)</term><term>Male (MeSH)</term><term>Malondialdehyde (metabolism)</term><term>Mice (MeSH)</term><term>Mice, Inbred ICR (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Phosphatidylinositol 3-Kinases (genetics)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Plant Extracts (pharmacology)</term><term>Superoxide Dismutase (metabolism)</term><term>Triglycerides (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alimentation riche en graisse (MeSH)</term><term>Animaux (MeSH)</term><term>Antioxydants (métabolisme)</term><term>Catalase (métabolisme)</term><term>Cholestérol HDL (sang)</term><term>Cholestérol LDL (sang)</term><term>Diabète expérimental (prévention et contrôle)</term><term>Extraits de plantes (pharmacologie)</term><term>Fragmentation de l'ADN (MeSH)</term><term>Glutathion (métabolisme)</term><term>Glutathione peroxidase (métabolisme)</term><term>Glycémie (métabolisme)</term><term>Hypoglycémiants (pharmacologie)</term><term>Hémoglobine A glycosylée (métabolisme)</term><term>Insuline (sang)</term><term>Lepidium sativum (composition chimique)</term><term>Lipides (sang)</term><term>Malonaldéhyde (métabolisme)</term><term>Mâle (MeSH)</term><term>Peroxydes lipidiques (métabolisme)</term><term>Phosphatidylinositol 3-kinases (génétique)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Régulation de l'expression des gènes (MeSH)</term><term>Souris (MeSH)</term><term>Souris de lignée ICR (MeSH)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Substrats du récepteur à l'insuline (génétique)</term><term>Substrats du récepteur à l'insuline (métabolisme)</term><term>Superoxide dismutase (métabolisme)</term><term>Transporteur de glucose de type 4 (génétique)</term><term>Transporteur de glucose de type 4 (métabolisme)</term><term>Triglycéride (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term><term>Insulin</term><term>Lipids</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucose Transporter Type 4</term><term>Insulin Receptor Substrate Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Blood Glucose</term><term>Catalase</term><term>Glucose Transporter Type 4</term><term>Glutathione</term><term>Glutathione Peroxidase</term><term>Glycated Hemoglobin A</term><term>Insulin Receptor Substrate Proteins</term><term>Lipid Peroxides</term><term>Malondialdehyde</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hypoglycemic Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lepidium sativum</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Lepidium sativum</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phosphatidylinositol 3-kinases</term><term>Substrats du récepteur à l'insuline</term><term>Transporteur de glucose de type 4</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term><term>Catalase</term><term>Glutathion</term><term>Glutathione peroxidase</term><term>Glycémie</term><term>Hémoglobine A glycosylée</term><term>Malonaldéhyde</term><term>Peroxydes lipidiques</term><term>Phosphatidylinositol 3-kinases</term><term>Substrats du récepteur à l'insuline</term><term>Superoxide dismutase</term><term>Transporteur de glucose de type 4</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term><term>Hypoglycémiants</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Diabetes Mellitus, Experimental</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Diabète expérimental</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cholestérol HDL</term><term>Cholestérol LDL</term><term>Insuline</term><term>Lipides</term><term>Triglycéride</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>DNA Fragmentation</term><term>Diet, High-Fat</term><term>Gene Expression Regulation</term><term>Male</term><term>Mice</term><term>Mice, Inbred ICR</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alimentation riche en graisse</term><term>Animaux</term><term>Fragmentation de l'ADN</term><term>Mâle</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée ICR</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>A mouse model in which diabetes mellitus was induced by low-dose streptozotocin (STZ) injection combined with a high-fat diet was used to study the effect of two water cress (Lepidium savitum) preparations. Diabetic mice were treated with dried cress powder or with water-soluble extracts (tested at two doses), together with proper control groups. The mice were evaluated after 4 weeks of continuous intervention for type 2 diabetic and associated markers. We determined blood glucose, body weight, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum insulin levels, and DNA integrity of hepatic cells. The concentrations of malondialdehyde (MDA) and lipid peroxide (LPO) and the activities of four enzymes that are part of the antioxidant defense system were determined in liver samples, as well as gene expression (by semi-quantitative reverse transcription polymerase chain reaction) and enzyme activity of IRS-1, IRS-2, PI3K, AKT-2, and GLUT4.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>After 4 weeks of intervention, the levels of TC, TG, and LDL cholesterol were significantly (P < 0.5) decreased and HDL cholesterol was significantly increased. Enzyme activities of liver superoxide dismutase, glutathione, glutathione peroxidase, and catalase were significantly increased, whereas MDA and LPO concentrations were significantly reduced. The transcription level of the five genes assessed was increased, with corresponding increases in protein expression.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Oral uptake of garden cress can significantly reduce the blood glucose and improve the blood lipid metabolism of diabetic mice. Considerable improvements in the activity of antioxidant defense enzymes were observed in type 2 diabetic mice that improved the body's antioxidant emergency response. © 2019 Society of Chemical Industry.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31875960</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0010</ISSN><JournalIssue CitedMedium="Internet"><Volume>100</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>Mar</Month><Day>30</Day></PubDate></JournalIssue><Title>Journal of the science of food and agriculture</Title><ISOAbbreviation>J Sci Food Agric</ISOAbbreviation></Journal><ArticleTitle>Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high-fat diet and streptozotocin.</ArticleTitle><Pagination><MedlinePgn>2074-2081</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jsfa.10230</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A mouse model in which diabetes mellitus was induced by low-dose streptozotocin (STZ) injection combined with a high-fat diet was used to study the effect of two water cress (Lepidium savitum) preparations. Diabetic mice were treated with dried cress powder or with water-soluble extracts (tested at two doses), together with proper control groups. The mice were evaluated after 4 weeks of continuous intervention for type 2 diabetic and associated markers. We determined blood glucose, body weight, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum insulin levels, and DNA integrity of hepatic cells. The concentrations of malondialdehyde (MDA) and lipid peroxide (LPO) and the activities of four enzymes that are part of the antioxidant defense system were determined in liver samples, as well as gene expression (by semi-quantitative reverse transcription polymerase chain reaction) and enzyme activity of IRS-1, IRS-2, PI3K, AKT-2, and GLUT4.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After 4 weeks of intervention, the levels of TC, TG, and LDL cholesterol were significantly (P < 0.5) decreased and HDL cholesterol was significantly increased. Enzyme activities of liver superoxide dismutase, glutathione, glutathione peroxidase, and catalase were significantly increased, whereas MDA and LPO concentrations were significantly reduced. The transcription level of the five genes assessed was increased, with corresponding increases in protein expression.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Oral uptake of garden cress can significantly reduce the blood glucose and improve the blood lipid metabolism of diabetic mice. Considerable improvements in the activity of antioxidant defense enzymes were observed in type 2 diabetic mice that improved the body's antioxidant emergency response. © 2019 Society of Chemical Industry.</AbstractText><CopyrightInformation>© 2019 Society of Chemical Industry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xi</ForeName><Initials>X</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8103-6173</Identifier><AffiliationInfo><Affiliation>School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Huaibo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Fangfang</ForeName><Initials>F</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7315-7194</Identifier><AffiliationInfo><Affiliation>School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yudong</ForeName><Initials>Y</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7741-965X</Identifier><AffiliationInfo><Affiliation>School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Sci Food Agric</MedlineTA><NlmUniqueID>0376334</NlmUniqueID><ISSNLinking>0022-5142</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008076">Cholesterol, HDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051275">Glucose Transporter Type 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006442">Glycated Hemoglobin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007004">Hypoglycemic 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diabetes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>12</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31875960</ArticleId><ArticleId 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